Mike's Notes
In 2014, I read an article in Scientific American by Markus Covert at
Stanford about the successful computer cellular simulation of mycoplasma. It
was a fascinating article that made me think about PIPI and whether it could
have been better built during 2005-2008.
When my wife and I left Christchurch in 2014 to start a new life, I became curious about modern cloud computing and read a great deal. Then, I realised that PIPI was a very early form of cloud computing, and many of its features were 10 years ahead of their time. What a waste!
By 2016, I was mad about missing the opportunity and decided to rebuild PIPI as a core platform from memory.
2017 to 2019, PIPI 6 was built by fusing the rebuilt core platform with Covert Lab's open-source cellular simulation software. This process was challenging and resulted in an unusual architecture. Every process was given a random probability, with many positive and negative feedback loops. It was like composing music. (In hindsight, synesthesia helped a lot.)
Resources
- https://en.wikipedia.org/wiki/Markus_W._Covert
- https://www.scientificamerican.com/article.cfm?id=scientists-successfully-model-a-living-cell-with-software
- https://www.covert.stanford.edu/
- https://profiles.stanford.edu/markus-covert
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413483
- https://www.covert.stanford.edu/publications
- https://www.covert.stanford.edu/_files/ugd/f6999c_bd641d2b9dd9443e9ed3768568b50c5c.pdf
- https://www.wholecellviz.org/viz.php
A Computational Whole-Cell Model Predicts Genotype From Phenotype
A 2013 talk by Markus Covert at the Qualcomm Institute.